学习与科研经历

1995年-2000年，重庆医科大学 预防医学专业获学士学位

2003年-2008年，复旦大学免疫学专业获博士学位（硕博连读）

2010年-2011年美国路易维尔大学 博士后

2011年-至今 遵义医科大学 免疫学教研室

主要研究方向

肿瘤免疫学

主要学术兼职

美国免疫学会（AAI）会员

中国免疫学会全国理事

贵州省免疫学副理事长

国际期刊Mol Ther、Nano Res、Sig Tran Tar Ther等审稿人

获得的主要荣誉

教育部新世纪优秀人才

贵州省第5批省管核心专家/第7批省管专家

中国免疫学会青年学者

贵州省“十、百层次”高层次创新型人才

贵州省青年科技奖等

教学专著

参编： 《医学免疫学》 孙万邦主编 科学技术出版社 2018年

承担的教学任务

承担本科生、研究生《医学免疫学》、《免疫学进展》、《高级免疫学技术》等课程教学

主要科研项目

近年来，先后主持国家自然科学基金面上/地区/青年项目、贵州省基础重点项目、贵州省科技支撑计划等项目10余项

专利

无

代表性论文

近年来，以通讯作者发表SCI论文30余篇，部分代表性论文如下：

[1] Tao Y, Zhao J, Rao L, Yang S, Zhang G, Guo M, Chen C,Xu L*.Alterations in thymocyte populations under conditions of endotoxin tolerance. Chinese Med J, 2021.134(15):1855-1865.

[2] Zhao X,Yang J,Huang R,Guo M,Zhou Y*,Xu L*. The role and its mechanism of intermittent fasting in tumors: friend or foe?Cancer Biol Med, 2021, 18(1):63-73.

[3] Zhao J, Chu F, Xu H, Guo M, Shan S，Zheng W, Tao Y, Zhou Y, Hu Y, Chen C, Ren T*,Xu L*.^.C/EBPα/miR-7 controls CD4⁺T cell activation and function and orchestrates experimental autoimmune hepatitis in mice. Hepatology, 2021.74(1):379-396. doi/10.1002/hep.31607.

[4] Chen H, Guo M, Yue D, Zhao J, Ding T, Zhou Y, Chen C, Liang G*,Xu L*. MicroRNA-7 Negatively Regulates Toll-Like Receptor 4 Signaling Pathway through FAM177A. Immunology, 2021,162(1):44-57.

[5] Mao L, Zhou Y, Chen L，Hu L, Liu S, Zheng W，Zhao J, Guo M, Chen Chao, He Z*,Xu L*. Identification of atypical mitogen-activated protein kinase MAPK4as a novel regulator in acute lung injury. Cell Biosci, 2020. 10:121.

[6] Zhao J, Zhou Y, Guo M, Yue D, Chen C, Liang G*,Xu L*. MicroRNA-7: expression and function in brain physiological and pathological processes. Cell Biosci, 2020.10:77.

[7] Yue D, Zhao J, Chen H, Guo M, Chen C, Zhou Y,Xu L*. MiRNA-7, synergizes with RORα, negatively controls the pathology of Brain Tissue Inflammatory. J Neuroinflammation, 2020.17(1):28.

[8] Din T, Zhou Y, Long R, Chen C, Zhao J, Cui P, Guo M, Liang G,Xu L*. DUSP8 Phosphatase: Structure, Functions, Expression Regulation and the Role in Human Diseases. Cell Biosci, 2019.9:70.

[9] Ding T, Cui P, Zhou Y, Chen C, Zhao J, Wang H, Guo M, He Z,Xu L*. Antisense oligonucleotides against microRNA-21 inhibited the growth and metastasis of colorectal carcinoma cells via DUSP8 pathway. Mol Ther Neucli ACIDS. 2018.13:244-255.

[10]Wang H, Liu S, Jia L, Chu F, Zhou Y, He Z, Guo M, Chen C,Xu L*. Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy. Cancer Cell Inter, 2018, 18:101.

[11]Chen C, Yue D, Lei L, Wang H, Jia L, Zhou Y, Liu S, Ding T, Guo M,Xu L*. Promoter-operating Targeted expression of Gene therapy in cancer: current stage and prospect.Mol Ther Neucli ACIDS. 2018, 11(6):508-514.

[12]Lei L, Chen C, Zhao J, Wang H, Guo M, Zhou Y, Luo J, Zhang J,Xu L*.Targeted expression of miR-7 operated by TTF-1 promoter inhibited the growth of human lung cancer through NDUFA4 pathway.Mol Ther Nucleic Acids, 2017, 6(3):183-197.

[13]Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, Qin N, Zheng J, Zhang J,Xu L*.MicroRNA-7 deficiency ameliorates the pathologies of Acute Lung Injury through Elevating KLF4.Front Immunol, 2016. 7:389.

[14]Hu Y, Wang C, Li Y, Zhao J, Chen C, Zhou Y, Tao Y, Guo M, Qin N, Ren T, Wen Z,Xu L*. MiR-21 controlsin situexpansion of CCR6⁺regulatory T cells through PTEN/AKT pathway in breast cancer.Immunol Cell Biol,2015. 93(8):753-64.

[15] Guo ZL, Wen ZK, Qin AD, Zhou Y, Ren T,Xu L*. Antisense oligonucleotides treatment enhanced the recovery of acute lung injury through IL-10 secreting M2 like macrophages-induced expansion of CD4⁺regulatory T cells.J Immunol, 2013,190(8):4337-48.

联系方式

E-mail：xulinzhouya@163.com